Yes. CDRouter does not directly configure the physical layer attributes of the Ethernet interfaces it uses for testing. CDRouter should work with any Ethernet interface that is properly installed, configured, and supported by the host system, provided an Ethernet link can be established between the CDRouter host system and the device under test.
For more information on the recommended configuration of all Ethernet interfaces in the host system, please see this Knowledge Base article: How should I configure my Ethernet interfaces for CDRouter?